Stem cells hold great promise in tissue engineering and regenerative medicine due to their unique ability to self-renew and differentiate into specialized cell types. However, the lack of non-destructive monitoring systems makes it difficult to identify and characterize differentiated cells before transplantation without affecting cell viability. Thus, developing a non-destructive method to analyze cell function is highly desirable for enhancing stem cell-based therapies. Recently, nanomaterial-based scaffolds, such as nanoarrays, have made significant advancements in controlling stem cell differentiation and monitoring the differentiation status in real-time. This review highlights recent progress in the synthesis methods of nanoarrays and their applications in controlling stem cell fate and electrochemically monitoring live cell functions. We believe this review provides concise guidelines for developing novel nanoarrays and fosters interest in live cell study applications. A technology that can both control and monitor stem cell fate and function will be a significant advancement in accelerating stem cell therapies. -Scientific Journal cover design by scapiens

https://pubs.rsc.org/en/content/articlelanding/2020/nr/c9nr10963c#!divAbstract