In mammals, the master circadian clock aligns daily physiological and behavioral rhythms with the day-night cycle. Disruptions in this synchrony can increase the risk of chronic diseases, but can be treated by adjusting the circadian clock using methods like melatonin or CK1δ/ε inhibitors. Research using a systems pharmacology model and experiments with cynomolgus monkeys has shown that light significantly influences the circadian phase delay caused by CK1δ/ε inhibition in diurnal species like humans and monkeys, more so than in nocturnal mice. The effect also depends on endogenous PER2 protein levels, which vary based on the molecular cause of circadian disruption and the patient’s lighting environment. To address these variations, an adaptive chronotherapeutics approach was developed to tailor dosing regimens for restoring normal circadian phases. This research highlights the role of photosensitivity in the efficacy of circadian-modulating drugs and supports precision medicine for treating circadian disruptions. -Scientific Journal cover design by scapiens.
[Scientific Journal cover design] Low-Thermal-Budget Fluorite-Structure Ferroelectrics for Future Electronic Device Applications
In article number 2100028, Jiyoung Kim, Si Joon Kim, and their team review key factors involved in developing fluorite-structure ferroelectrics
