One of the emerging topics in biotechnology is the use of natural receptors such as G protein-coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular receptors, due to their molecular specificity. These membrane proteins, except intracellular receptors, can detect extracellular stimuli. Researchers have embedded these natural receptors in cell membranes to create human sense-mimicking platforms using techniques like electrochemical impedance spectroscopy, quartz crystal microbalances, surface plasmon resonance, and surface acoustic waves. By integrating conducting nanomaterials with natural receptors, highly sensitive and selective responses to target molecules are achieved. This allows for the development of nanobioelectronic noses for odors, nanobioelectronic tongues for tastes, and G-protein-coupled receptor sensors for hormones and various chemicals. Natural receptors can be produced in forms like peptides, proteins, nanovesicles, and nanodiscs, providing an ultra-low limit of detection. This review discusses biosensors with natural receptors, focusing on sensors that combine natural receptors with conducting nanomaterials. We cover the fabrication of conducting nanomaterials, production and characteristics of natural receptors, immobilization technology, and sensing applications, along with future perspectives in industries such as food, cosmetics, and healthcare. – Scientific Journal cover design by scapiens
[Scientific Journal cover design] Low-Thermal-Budget Fluorite-Structure Ferroelectrics for Future Electronic Device Applications
In article number 2100028, Jiyoung Kim, Si Joon Kim, and their team review key factors involved in developing fluorite-structure ferroelectrics
