A recent study has achieved stereospecific cross-coupling of chiral α-borylalkylcopper species with aryl bromides using a Pd catalyst. The process involves a copper catalyst combined with a chiral NHC ligand to generate enantioenriched secondary α-borylorganocopper species through the addition of Cu–Bpin to alkenyl boramides. The subsequent cross-coupling with aryl bromides, facilitated by a palladium-XPhos catalyst, successfully yields the desired products. Notably, using 1,2-disubstituted borylalkenes with a 1,8-naphthalenediaminatoboryl (Bdan) group results in anti-diborylalkanes as single diastereomers with high enantioselectivity up to 96.5:3.5 er. These compounds can be further oxidized to form anti-1,2-dihydroxyl compounds. -Journal cover design by scapiens
[Scientific Journal cover design] Low-Thermal-Budget Fluorite-Structure Ferroelectrics for Future Electronic Device Applications
In article number 2100028, Jiyoung Kim, Si Joon Kim, and their team review key factors involved in developing fluorite-structure ferroelectrics
