A new method for highly enantioselective conjugate addition reactions of arylboronic acids to 2-substituted chromones has been developed using palladium complexes with novel chiral Pyridine-Dihydroisoquinoline (PyDHIQ) ligands. This process allows for the creation of chromanones with tetrasubstituted stereocenters with high enantioselectivity. Various arylboronic acids and 2-substituted chromones can be utilized in this catalytic reaction, yielding chiral tetrasubstituted chromanones with excellent results (up to 98% yields and 99% ee in 25 examples).-Science journal cover design by scapiens

https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc00412j#!divAbstract