Niemann-Pick disease type C (NPC) is a fatal neurodegenerative disorder with no effective treatment currently available. In a recent study, graphene quantum dots (GQDs) have been proposed as a promising therapeutic candidate for NPC. GQDs, known for their ability to penetrate the blood-brain barrier and minimal long-term toxicity, have shown potential in reducing cholesterol accumulation in lysosomes and promoting autophagy. This treatment also restores defective autophagic flux and decreases the abnormal accumulation of autophagic vacuoles. Furthermore, GQDs help protect Purkinje cells in the cerebellum and reduce microglial activation, highlighting their potential in treating NPC and related neurodegenerative disorders.-Science Journal cover design by scapiens
[Scientific Journal cover design] Low-Thermal-Budget Fluorite-Structure Ferroelectrics for Future Electronic Device Applications
In article number 2100028, Jiyoung Kim, Si Joon Kim, and their team review key factors involved in developing fluorite-structure ferroelectrics
