[Science Journal Cover design] MicroRNA Detection: Single Functionalized pRNA/Gold Nanoparticle for Ultrasensitive MicroRNA Detection Using Electrochemical Surface-Enhanced Raman Spectroscopy (Adv. Sci. 3/2020)

Science Journal Cover design

Peixuan Guo, Jeong-Woo Choi, and their team have developed monofunctionalized gold nanoparticles (AuNPs) featuring a single RNA three-way junction (3WJ) motif for ultra-sensitive miRNA biosensing. Utilizing electrochemical surface-enhanced Raman spectroscopy (EC-SERS), the presence of miRNA-155 triggers the displacement of the 3WJ structure, leading to a significant increase in both electrochemical and SERS signals. This innovative approach offers a highly sensitive method for detecting miRNA-155.-Journal cover design by scapiens

https://onlinelibrary.wiley.com/doi/10.1002/advs.202070012

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