In the quest for effective preclinical drug screening, early detection of cardiac toxicity is vital. Traditional biosensing platforms for cardiomyocytes have typically focused on either mechanophysiology or electrophysiology, but not both. Our innovative “multifunctional microphysiological system” or “organs-on-chips” addresses this gap by simultaneously measuring the mechanical and electrical properties of cardiomyocytes. This advanced device can quickly detect drug-induced cardiac toxicity in real time, making it a significant tool for drug discovery and postmarketing surveillance. Our studies demonstrate a direct correlation between contraction force and cell impedance of cardiomyocytes when exposed to drugs such as verapamil, astemizole, and lidocaine, offering deeper insights into drug effects on heart cells in vitro. -Scientific Journal cover by scapiens
[Scientific Journal cover design] Low-Thermal-Budget Fluorite-Structure Ferroelectrics for Future Electronic Device Applications
In article number 2100028, Jiyoung Kim, Si Joon Kim, and their team review key factors involved in developing fluorite-structure ferroelectrics
