Microfluidic channel-coupled 3D quartz nanohole arrays for high capture and release efficiency of BT20 cancer cells

Nanostructured materials, such as silicon nanowires and quartz nanostructures, are emerging as a promising class for capturing and analyzing rare tumor cells, including circulating tumor cells (CTCs) in cancer patients’ blood. Our 3D quartz nanohole array (QNHA) system demonstrates high efficiency in capturing and releasing these cells. This technology, combined with a microfluidic channel, achieves capture yields of 85–91% and release rates over 90%, offering a powerful tool for cell therapy and molecular analysis.

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